Gambino crime boss Francesco “Franky Boy” Cali was gunned down and run over outside his Staten Island home Wednesday night, reported the New York Post.

The hit took place around 9:20 p.m. Cali’s wife and young children were inside, police sources confirmed.

The assassination of the 53-year-old mob boss is just part of a recent rise in mafia activity in the New York area over the past couple of months.

A 911 caller described hearing 6 or 7 shots outside the lavish brick mansion, before a man in a blue pickup truck fled the scene. Police sources say that it was unconfirmed how many times Cali had been hit.

An ambulance brought Cali to Staten Island University Hospital North, where he was pronounced dead.

Frank Cali was murdered outside of his Staten Island home on Wednesday night. (Getty Images/HANDOUT)

An unnamed source referred to the hit as “disrespectful” because the attacker went so far as to come to Cali’s family home in an outer borough.

Cali was described as a “real quiet old-school boss,” quiet, unlike his predecessor, “Dapper Don” John Gotti.

Neighbors were shocked by the events.

“I’ve seen the [mob] movies . . . but I’ve never seen any activity that we feel at all that there’s something strange about this area,” said Prashant Ranyal, a neighbor from a few blocks down.

“You never know who your neighbors are,” said another.

This is the first slaying of a mob boss in New York City since 1985, when John Gotti called for the murder of Paul Castellano, who was the Gambino boss at the time.

A number of authorities are investigating the murder including the FBI. Sources say they are looking into whether it was a hit directed by one of the “Five Families” or if it was a rogue “cowboy” gunman.

Cali had only been previously convicted of a single crime – extortion from shaking down a trucker working at a proposed NASCAR track. Cali served just 16 months for the act.

In recent years, Cali was reportedly working in the drug trade, specifically focusing on OxyContin and heroin.